Transplantation with adipose tissue derived stem cells increased follicle survival in frozen–thawed human ovarian tissue.
A recent paper published in 'Human Reproduction' by Diego Manavella et al looked at a two-step transplantation process using adipose tissue derived stem cells in which they found increased follicle survival by enhancing vascularization in xenografted frozen–thawed human ovarian tissue.
The team from the Gynaecology Research Unit, Institut de Recherche Expérimentale et Clinique, UCL Louvain, who use Planer controlled rate freezers, found that higher rates of oxygenation and vascularization of ovarian tissue, as well as increased follicle survival rates, were detected in the early post-grafting period. The results suggested that the proposed transplantation procedure with ASCs is a promising step towards potentially solving the problem of massive follicle loss after ovarian tissue grafting.
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Article: Human Reproduction, Volume 33, Issue 6, 1 June 2018, Pages 1107–1116,
